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KMID : 0043320200430111093
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Archives of Pharmacal Research
2020 Volume.43 No. 11 p.1093 ~ p.1113
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Beta resorcylic acid lactones (RALs) from fungi: chemistry, biology, and biosynthesis
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Bang Sung-Hee
Shim Sang-Hee
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Abstract
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β-Resorcylic acid lactones (RALs) are one of the major polyketides produced by fungi, and some of them have a diverse array of biological activities. Most RALs feature a 14-membered macrocyclic ring fused to β-resorcylic acid (2,4-dihydroxybenzoic acid). In this review, more than 100 RAL-type of compounds are structurally classified into three groups; 14-membered RALs with 17R configuration, 14-membered RALs with 17S configuration, and benzopyranones/benzofuranones, and they are reviewed comprehensively in terms of chemistry, biological activities, and biosynthetic pathways.
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KEYWORD
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Natural products, Fungal secondary metabolites, β-Resorcylic acid lactones (RALs), Polyketides
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